Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non‐muscle invasive bladder cancer

Miyake, Makito; Sugano, Kokichi; Sugino, Hitomi; Imai, Kazuho; Matsumoto, Eri; Maeda, Koshi; Fukuzono, Shinich; Ichikawa, Hiroki; Kawashima, Kiyotaka; Hirabayashi, Kaoru; Kodama, Tetsuro; Fujimoto, Hiroyuki; Kakizoe, Tadao; Kanai, Yae; Fujimoto, Kiyohide; Hirao, Yoshihiko

doi:10.1111/j.1349-7006.2009.01334.x

Public

Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non‐muscle invasive bladder cancer

Published in Cancer Science • Sep 1, 2009

Authors:

Makito Miyake

Kokichi Sugano

Hitomi Sugino

Abstract

The fibroblast growth factor receptor (FGFR)-3 gene encodes a receptor tyrosine kinase that is frequently mutated in non-muscle invasive bladder cancer (NMIBC). A sensitive and quantitative assay using peptide nucleic acid-mediated real-time PCR was developed for detecting FGFR3 mutations in the uri...

Subject

Bladder cancer

Urine

Fibroblast growth factor receptor 3

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