Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease

Ghezzi, Silvia; Galli, Laura; Kajaste‐Rudnitski, Anna; Turrini, Filippo; Marelli, Sara; Toniolo, Daniela; Casoli, Claudio; Riva, Agostino; Poli, Guido; Castagna, Antonella; Vicenzi, Elisa

doi:10.1097/01.aids.0000432474.76873.5f

Public

Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease

Published in AIDS • Aug 6, 2013

Authors:

Silvia Ghezzi

Laura Galli

Anna Kajaste‐Rudnitski

Abstract

OBJECTIVE(S): Tripartite motif-containing 22 (TRIM22) is an interferon-induced protein that inhibits HIV-1 transcription and replication in vitro. Two single nucleotide missense polymorphisms rs7935564A/G (SNP-1) and rs1063303C/G (SNP-2) characterize the coding sequence of human TRIM22 gene. We test...

Subject

Single-nucleotide polymorphism

SNP

Biology

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