Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

C. Harvey, Richard; G. Mullighan, Charles; Chen, I‐Ming; Wharton, Walker; M. Mikhail, Fady; J. Carroll, Andrew; Kang, Huining; Liu, Wei; K. Dobbin, Kevin; A. Smith, Malcolm; L. Carroll, William; Devidas, Meenakshi; Paul Bowman, W.; M. Camitta, Bruce; H. Reaman, Gregory; P. Hunger, Stephen; R. Downing, James; L. Willman, Cheryl

doi:10.1182/blood-2009-09-245944

Public

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

Published in Blood • Feb 5, 2010

Authors:

Richard C. Harvey

Charles G. Mullighan

I‐Ming Chen

Abstract

Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia revealed 29 of 207 cases (14%) with markedly elevated expression of CRLF2 (cytokine receptor-like factor 2). Each of the 29 cases harbored a genomic rearrangement of CRLF2: 18 of 29 (...

Subject

Medicine

Gene expression profiling

Cancer research

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