Impact of Genotype-Guided Dosing on Anticoagulation Visits for Adults Starting Warfarin: A Randomized Controlled Trial

E Jonas, Daniel; P. Evans, James; L. McLeod, Howard; Brode, Shannon; A. Lange, Leslie; Lynn Young, Mary; Bryant Shilliday, Betsy; Martensen Bardsley, Michelle; J Swinton-Jenkins, Nia; E. Weck, Karen

doi:10.2217/pgs.13.145

Public

Impact of Genotype-Guided Dosing on Anticoagulation Visits for Adults Starting Warfarin: A Randomized Controlled Trial

Published in Pharmacogenomics • Oct 1, 2013

Authors:

Daniel E Jonas

James P. Evans

Howard L. McLeod

Abstract

AIM: This study aimed to assess the effectiveness of genotype-guided warfarin dosing. PATIENTS & METHODS: A total of 109 adults were randomized to receive initial dosing as determined by an algorithm containing genetic (VKORC1 and CYP2C9) plus clinical information or only clinical information. Prima...

Subject

Dosing

Warfarin

Randomized controlled trial

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