Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

Snelders, Eveline; A. L. van der Lee, Henrich; Kuijpers, Judith; J. M. M. Rijs, Anthonius; Varga, János; A. Samson, Robert; Mellado, Emilia; Rogier T. Donders, A.; J. G. Melchers, Willem; E. Verweij, Paul

doi:10.1371/journal.pmed.0050219

Public

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

Published in PLoS Medicine • Nov 7, 2008

Authors:

Eveline Snelders

Henrich A. L. van der Lee

Judith Kuijpers

Abstract

BACKGROUND: Resistance to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive aspergillosis. The prevalence of azole resistance in A. fumigatus is unknown. We investigated the prevalence and spread of azole resistance using our culture collection th...

Subject

Aspergillus fumigatus

Posaconazole

Itraconazole

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