Protective Effects of Fresh Frozen Plasma on Vascular Endothelial Permeability, Coagulation, and Resuscitation After Hemorrhagic Shock Are Time Dependent and Diminish Between Days 0 and 5 After Thaw

Pati, Shibani; Matijevic, Nena; Doursout, Marie–Françoise; C. Ko, Tien; Cao, Yanna; Deng, Xiyun; A. Kozar, Rosemary; Hartwell, Elizabeth; L. Conyers, Jodie; B. Holcomb, John

doi:10.1097/ta.0b013e3181e453d4

Public

Protective Effects of Fresh Frozen Plasma on Vascular Endothelial Permeability, Coagulation, and Resuscitation After Hemorrhagic Shock Are Time Dependent and Diminish Between Days 0 and 5 After Thaw

Published in The Journal of Trauma: Injury, Infection, and Critical Care • Jul 1, 2010

Authors:

Shibani Pati

Nena Matijevic

Marie–Françoise Doursout

Abstract

BACKGROUND: Clinical studies have shown that resuscitation with fresh frozen plasma (FFP) is associated with improved outcome after severe hemorrhagic shock (HS). We hypothesized that in addition to its effects on hemostasis, FFP has protective and stabilizing effects on the endothelium that transla...

Subject

Resuscitation

Hemostasis

Fresh frozen plasma

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