Defining a binding pocket for sulfonylureas in ATP‐sensitive potassium channels

H. Vila‐Carriles, Wanda; Zhao, Guiling; Bryan, Joseph

doi:10.1096/fj.06-6730hyp

Public

Defining a binding pocket for sulfonylureas in ATP‐sensitive potassium channels

Published in The FASEB Journal • Nov 16, 2006

Authors:

Wanda H. Vila‐Carriles

Guiling Zhao

Joseph Bryan

Abstract

Sulfonylurea receptors SUR1 and SUR2 are the regulatory subunits of K(ATP) channels. Their differential affinity for hypoglycemic sulfonylureas provides a basis for the selectivity of these compounds for different K(ATP) channel isoforms. Sulfonylureas have a 100- to 1000-fold greater affinity for S...

Subject

Sulfonylurea receptor

Transmembrane domain

Chemistry

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