Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

A. Mitchell, Jane; Akarasereenont, Pravit; Thiemermann, Christoph; Flower, R.J.; R. Vane, John

doi:10.1073/pnas.90.24.11693

Public

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Published in Proceedings of the National Academy of Sciences • Dec 15, 1993

Authors:

Jane A. Mitchell

Pravit Akarasereenont

Christoph Thiemermann

Abstract

Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin presumably in pathological conditions, such as inflammation. Therefore, we have assessed the ...

Subject

Cyclooxygenase

Ibuprofen

Aspirin

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