Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies.

M, Colom-Cadena; E, Gelpi; S, Charif; O, Belbin; R, Blesa; MJ, Martí; J, Clarimón; A, Lleó

doi:10.1097/nen.0000000000000018

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Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies.

Shared by NobleBlocks on Dec 1, 2013 • 12:00 AM UTC

Authors:

Colom-Cadena M

Gelpi E

Charif S

Abstract

Dementia with Lewy bodies (DLB) is pathologically characterized by α-synuclein aggregates in the brain. Most patients with DLB also show cerebral Alzheimer disease-type pathology (i.e. β-amyloid plaques and hyperphosphorylated tau deposits). It is unclear whether this overlap is coincidental or driv...

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