Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

Dompierre, Jim; D. Godin, Juliette; C. Charrin, Bénédicte; P. Cordelières, Fabrice; J. King, Stephen; Humbert, Sandrine; Saudou, Frédéric

doi:10.1523/jneurosci.0037-07.2007

Public

Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

Published in Journal of Neuroscience • Mar 28, 2007

Authors:

Jim Dompierre

Juliette D. Godin

Bénédicte C. Charrin

Abstract

A defect in microtubule (MT)-based transport contributes to the neuronal toxicity observed in Huntington's disease (HD). Histone deacetylase (HDAC) inhibitors show neuroprotective effects in this devastating neurodegenerative disorder. We report here that HDAC inhibitors, including trichostatin A (T...

Subject

Acetylation

HDAC6

Trichostatin A

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