A Tyrosine Kinase Created by Fusion of the <i>PDGFRA</i> and <i>FIP1L1</i> Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

Cools, Jan; J. DeAngelo, Daniel; Gotlib, Jason; H. Stover, Elizabeth; D. Legare, Robert; E. Cortes, Jörge; L. Kutok, Jeffrey; Clark, Jennifer; Galinsky, Ilene; D. Griffin, James; C.P. Cross, Nicholas; Tefferi, Ayalew; Malone, James; Alam, Rafeul; L. Schrier, Stanley; Schmid, Janet; G. Rose, Michal; Vandenberghe, Peter; Verhoef, Gregor; Boogaerts, Marc; Włodarska, Iwona; M. Kantarjian, Hagop; Marynen, Peter; Coutré, Steven; M. Stone, Richard; Gary Gilliland, D.

doi:10.1056/nejmoa025217

Public

A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

Published in New England Journal of Medicine • Mar 26, 2003

Authors:

Jan Cools

Daniel J. DeAngelo

Jason Gotlib

Abstract

BACKGROUND: Idiopathic hypereosinophilic syndrome involves a prolonged state of eosinophilia associated with organ dysfunction. It is of unknown cause. Recent reports of responses to imatinib in patients with the syndrome suggested that an activated kinase such as ABL, platelet-derived growth factor...

Subject

Imatinib

Hypereosinophilic syndrome

Medicine

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