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Sex differences in CYP3A activity using intravenous and oral midazolam.

Published in Clinical pharmacology and therapeutics • Nov 1, 2006
Authors:
Maylee Chen
,
Lei Ma
,
George L Drusano

Abstract

BACKGROUND: Studies examining sex differences in CYP3A activity have produced conflicting results. Our objective is to investigate whether sex differences exist in CYP3A activity as assessed by intravenous (IV) or oral midazolam pharmacokinetic analysis in healthy volunteers. METHODS: Data from 13 p...

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