Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

Nagai, Shigeki; Dubrana, Karine; Tsai-Pflugfelder, Monika; Davidson, Marta; Michelle Roberts, Tania; W. Brown, Grant; Varela, Elisa; Hediger, Florence; M. Gasser, Susan; J. Krogan, Nevan

doi:10.1126/science.1162790

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Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

Published in Science • Oct 23, 2008

Authors:

Shigeki Nagai

Karine Dubrana

Monika Tsai-Pflugfelder

Abstract

Recent findings suggest important roles for nuclear organization in gene expression. In contrast, little is known about how nuclear organization contributes to genome stability. Epistasis analysis (E-MAP) using DNA repair factors in yeast indicated a functional relationship between a nuclear pore su...

Subject

Ubiquitin

Ubiquitin ligase

DNA ligase

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