Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life

C. G. Weaver, Ian; A. Champagne, Frances; E. Brown, Shelley; Dymov, Sergiy; Sharma, Shakti; J. Meaney, Michael; Szyf, Moshe

doi:10.1523/jneurosci.3652-05.2005

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Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life

Shared by NobleBlocks on Nov 23, 2005 • 12:00 AM UTC

Authors:

Ian C. G. Weaver

Frances A. Champagne

Shelley E. Brown

Abstract

Stress responses in the adult rat are programmed early in life by maternal care and associated with epigenomic marking of the hippocampal exon 1 7 glucocorticoid receptor (GR) promoter. To examine whether such epigenetic programming is reversible in adult life, we centrally infused the adult offspri...

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