Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.

Khan, Muhammad; Li, Ting; Khalil Ahmad Khan, Muhammad; Rasul, Azhar; Nawaz, Faisal; Sun, Meiyan; Zheng, Yongchen; Ma, Tonghui

doi:10.1155/2013/719858

Public

Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.

Shared by NobleBlocks on Jan 1, 2013 • 12:00 AM UTC

Authors:

Muhammad Khan

Ting Li

Muhammad Khalil Ahmad Khan

Abstract

Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells and has been implicated in apoptosis resistance and tumorigenesis. Alantolactone, a sesquiterpene lactone, has been shown to possess anticancer activities in various cancer cell lines. In ...

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