Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction

Noman Khan, Muhammad; Li, Ting; Khalil Ahmad Khan, Muhammad; Rasul, Azhar; A. Nawaz, Faisal; Sun, Meiyan; Zheng, Yongchen; Ma, Tonghui

doi:10.1155/2013/719858

Public

Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction

Published in BioMed Research International • Dec 27, 2012

Authors:

Muhammad Noman Khan

Ting Li

Muhammad Khalil Ahmad Khan

Abstract

Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells and has been implicated in apoptosis resistance and tumorigenesis. Alantolactone, a sesquiterpene lactone, has been shown to possess anticancer activities in various cancer cell lines. In ...

Subject

Apoptosis

Glutathione

Cell biology

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