Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China

Zhu, Fengcai; Xu, Wenbo; Xia, Jielai; Liang, Zhenglun; Liu, Yan; Zhang, Xuefeng; Tan, Xiaojuan; Wang, Ling; Mao, Qunying; Wu, Junyu; Hu, Yuemei; Ji, Tianjiao; Song, Li-Fei; Qi, Liang; Zhang, Baomin; Gao, Qiang; Li, Jingxin; Wang, Shenyu; Hu, Yuansheng; Gu, Shanru; Zhang, Jianhua; Yao, Genhong; Gu, Jianxiang; Wang, Xushan; Zhou, Yuchun; Chen, Changbiao; Zhang, Minglei; Cao, Minquan; Wang, Junzhi; Wang, Hua; Wang, Nan

doi:10.1056/nejmoa1304923

Public

Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China

Published in New England Journal of Medicine • Feb 26, 2014

Authors:

Fengcai Zhu

Wenbo Xu

Jielai Xia

Abstract

BACKGROUND: Enterovirus 71 (EV71) is one of the major causative agents of outbreaks of hand, foot, and mouth disease or herpangina worldwide. This phase 3 trial was designed to evaluate the efficacy, safety, and immunogenicity of an EV71 vaccine. METHODS: We conducted a randomized, double-blind, pla...

Subject

Medicine

Enterovirus 71

Immunogenicity

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