Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

Raghow, Rajendra; E. Postlethwaite, Arnold; Keski‐Oja, Jorma; L. Moses, Harold; H Kang, A

doi:10.1172/jci112950

Public

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

Published in Journal of Clinical Investigation • Apr 1, 1987

Authors:

Rajendra Raghow

Arnold E. Postlethwaite

Jorma Keski‐Oja

Abstract

Transforming growth factor-beta (TGF beta), when injected subcutaneously into newborn mice, induces a rapid fibrotic response, stimulates chemotaxis, and elevates the rates of biosynthesis of collagen and fibronectin by fibroblasts in vitro. We explored the molecular mechanisms of TGF beta-mediated ...

Subject

Fibronectin

Procollagen peptidase

Messenger RNA

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