The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2.

P, Andre; Q, Wang; N, Wang; B, Gao; A, Schilit; MM, Halford; SA, Stacker; X, Zhang; Y, Yang

doi:10.1074/jbc.m112.414441

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The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2.

Shared by NobleBlocks on Nov 9, 2012 • 12:00 AM UTC

Authors:

Andre P

Wang Q

Wang N

Abstract

The Wnt signaling pathways control many critical developmental and adult physiological processes. In vertebrates, one fundamentally important function of Wnts is to provide directional information by regulating the evolutionarily conserved planar cell polarity (PCP) pathway during embryonic morphoge...

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