NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

Wree, Alexander; Eguchi, Akiko; D. McGeough, Matthew; A. Peña, Carla; D. Johnson, Casey; Canbay, Ali; M. Hoffman, Hal; E. Feldstein, Ariel

doi:10.1002/hep.26592

Public

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

Published in Hepatology • Jun 28, 2013

Authors:

Alexander Wree

Akiko Eguchi

Matthew D. McGeough

Abstract

UNLABELLED: Inflammasome activation plays a central role in the development of drug-induced and obesity-associated liver disease. However, the sources and mechanisms of inflammasome-mediated liver damage remain poorly understood. Our aim was to investigate the effect of NLRP3 inflammasome activation...

Subject

Pyroptosis

Inflammasome

Hepatocyte

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