Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

Tyzio, Roman; Nardou, Romain; C. Ferrari, Diana; Tsintsadze, Timur; Shahrokhi, Amene; Eftekhari, Sanaz; Khalilov, Ilgam; Tsintsadze, Vera; Brouchoud, Corinne; Chazal, Geneviève; Lemonnier, Éric; Lozovaya, Natalia; Burnashev, Nail; Ben‐Ari, Yehezkel

doi:10.1126/science.1247190

Public

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

Published in Science • Feb 6, 2014

Authors:

Roman Tyzio

Romain Nardou

Diana C. Ferrari

Abstract

We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism. During delivery and subsequently, hippocampal neurons in these models have elevated intracellular chloride ...

Subject

Oxytocin

Offspring

Excitatory postsynaptic potential

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