Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring.

Tyzio, Roman; Nardou, Romain; C Ferrari, Diana; Tsintsadze, Timur; Shahrokhi, Amene; Eftekhari, Sanaz; Khalilov, Ilgam; Tsintsadze, Vera; Brouchoud, Corinne; Chazal, Genevieve; Lemonnier, Eric; Lozovaya, Natalia; Burnashev, Nail; Ben-Ari, Yehezkel

doi:10.1126/science.1247190

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Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring.

Shared by NobleBlocks on Feb 7, 2014 • 12:00 AM UTC

Authors:

Roman Tyzio

Romain Nardou

Diana C Ferrari

Abstract

We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism. During delivery and subsequently, hippocampal neurons in these models have elevated intracellular chloride ...

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