Spiroindolones, a Potent Compound Class for the Treatment of Malaria

Rottmann, Matthias; McNamara, Case; K. S. Yeung, Bryan; C. S. Lee, Marcus; Zou, Bin; Russell, Bruce; Seitz, Patrick; M. Plouffe, David; V. Dharia, Neekesh; Tan, Jocelyn; B. Cohen, Steven; R. Spencer, Kathryn; E. González-Páez, Gonzalo; B. Lakshminarayana, Suresh; Goh, Anne; Suwanarusk, Rossarin; Jegla, Timothy; K. Schmitt, Esther; Beck, Hans-Peter; Brun, Reto; Nosten, Francois; Renia, Laurent; Dartois, Veronique; H. Keller, Thomas; A. Fidock, David; A. Winzeler, Elizabeth; T. Diagana, Thierry

doi:10.1126/science.1193225

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

Shared by NobleBlocks on Sep 3, 2010 • 12:00 AM UTC

Authors:

Matthias Rottmann

Case McNamara

Bryan K. S. Yeung

Abstract

Antimalarial Drug Candidate Spiroindolones were discovered as promising antimalarial drug candidates through a high-throughput screening approach that should be applicable to a range of neglected infectious diseases. Rottmann et al. (p. 1175 ; see the Perspective by Wells ) present the preclinical p...

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