FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

Zhao, Xu; Yang, Ying; Yang, Ying; Sun, Bao-Fa; Shi, Yue; Yang, Xin; Xiao, Wen; Hao, Ya-Juan; Ping, Xiaoli; Chen, Yusheng; Wang, Wenjia; Jin, Kang-Xuan; Wang, Xing; Huang, Chun-Min; Fu, Yu; Ge, Xiao-Meng; Song, Shu-Hui; Seok Jeong, Hyun; Yanagisawa, Hiroyuki; Niu, Yamei; Jia, Gui-Fang; Wu, Wei; Tong, Wei‐Min; Okamoto, Akimitsu; He, Chuan; M. Rendtlew Danielsen, Jannie; Wang, Xiu‐Jie; Yang, Yun‐Gui; Yang, Yun‐Gui

doi:10.1038/cr.2014.151

Public

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

Published in Cell Research • Nov 21, 2014

Authors:

Xu Zhao

Ying Yang

Abstract

The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-methyladenosine (m6A) in mRNA processing and adipogenesis remains largely unknown. We show that FTO expression and m6A levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only cat...

Subject

Adipogenesis

RNA splicing

Demethylase

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