The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

C. Staton, Penny; P. Hatcher, Jon; J. Walker, Deborah; Morrison, Alastair; M. Shapland, Ellen; P. Hughes, Jane; Chong, Elizabeth; K. Mander, Palwinder; J. Green, Paula; Billinton, Andy; Fulleylove, Michael; C. Lancaster, Hilary; Smith, J.; T. Bailey, Leigh; Wise, Alan; J. Brown, Andrew; Richardson, Jill; P. Chessell, Iain

doi:10.1016/j.pain.2008.04.006

Public

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

Published in Pain • May 29, 2008

Authors:

Penny C. Staton

Jon P. Hatcher

Deborah J. Walker

Abstract

It has been postulated that the G protein-coupled receptor, GPR55, is a third cannabinoid receptor. Given that the ligands at the CB(1) and CB(2) receptors are effective analgesic and anti-inflammatory agents, the role of GPR55 in hyperalgesia associated with inflammatory and neuropathic pain has be...

Subject

Pharmacology

Cannabinoid

Hyperalgesia

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