Whole-Genome Analysis of a Daptomycin-Susceptible Enterococcus faecium Strain and Its Daptomycin-Resistant Variant Arising during Therapy

T. Tran, Truc; Panesso, Diana; Gao, Hongyu; Hyeob Roh, Jung; M. Munita, José; Reyes, Jinnethe; Díaz, Lorena; A. Lobos, Elizabeth; Shamoo, Yousif; N. Mishra, Nagendra; S. Bayer, Arnold; E. Murray, Barbara; M. Weinstock, George; A. Arias, César

doi:10.1128/aac.01454-12

Public

Whole-Genome Analysis of a Daptomycin-Susceptible Enterococcus faecium Strain and Its Daptomycin-Resistant Variant Arising during Therapy

Published in Antimicrobial Agents and Chemotherapy • Nov 1, 2012

Authors:

Truc T. Tran

Diana Panesso

Hongyu Gao

Abstract

Development of daptomycin (DAP) resistance in Enterococcus faecalis has recently been associated with mutations in genes encoding proteins with two main functions: (i) control of the cell envelope stress response to antibiotics and antimicrobial peptides (LiaFSR system) and (ii) cell membrane phosph...

Subject

Daptomycin

Enterococcus faecium

Microbiology

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