Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

Nan, Xinsheng; R. Meehan, Richard; Bird, Adrian

doi:10.1093/nar/21.21.4886

Public

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

Published in Nucleic Acids Research • Jan 1, 1993

Authors:

Xinsheng Nan

Richard R. Meehan

Adrian Bird

Abstract

MeCP2 is a chromosomal protein which binds to DNA that is methylated at CpG. In situ immunofluorescence in mouse cells has shown that the protein is most concentrated in pericentromeric heterochromatin, suggesting that MeCP2 may play a role in the formation of inert chromatin. Here we have isolated ...

Subject

Biology

Library science

Classics

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