Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

Schwarte‐Waldhoff, Irmgard; V. Volpert, Olga; Bouck, Noël; Sipos, Bence; A. Hahn, Stephan; Klein‐Scory, Susanne; Lüttges, Jütta; Klöppel, Günter; Graeven, U.; Eilert-Micus, Christina; Hintelmann, Annette; Schmiegel, Wolff

doi:10.1073/pnas.97.17.9624

Public

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

Published in Proceedings of the National Academy of Sciences • Aug 15, 2000

Authors:

Irmgard Schwarte‐Waldhoff

Olga V. Volpert

Noël Bouck

Abstract

Smad4/DPC4 (deleted in pancreatic carcinoma, locus 4) is a tumor suppressor gene lost at high frequency in cancers of the pancreas and other gastrointestinal organs. Smad4 encodes a key intracellular messenger in the transforming growth factor beta (TGF-beta) signaling cascade. TGF-beta is a potent ...

Subject

Angiogenesis

Thrombospondin 1

Biology

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