Down-Regulation of Na<sup>+</sup>/K<sup>+</sup>ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

Almilaji, Ahmad; Szteyn, Kalina; Fein, Evelyn; Pakladok, Tatsiana; Muñoz, Carlos; Elvira, Bernat; Tasneem Towhid, Syeda; Alesutan, Ioana; Shumilina, Ekaterina; Bock, C.–Thomas; Kandolf, Reinhard; Läng, Florian

doi:10.1159/000350083

Public

Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

Published in Cellular Physiology and Biochemistry • Jan 1, 2013

Authors:

Ahmad Almilaji

Kalina Szteyn

Evelyn Fein

Abstract

BACKGROUND/AIMS: Human parvovirus B19 (B19V) may cause inflammatory cardiomyopathy (iCMP) which is accompanied by endothelial dysfunction. The B19V capsid protein VP1 contains a lysophosphatidylcholine producing phospholipase A2 (PLA) sequence. Lysophosphatidylcholine has in turn been shown to inhib...

Subject

Lysophosphatidylcholine

Capsid

Molecular biology

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