Presence and Bronchomotor Activity of Protease-Activated Receptor-2 in Guinea Pig Airways

Luigi Massimo Ricciardolo, Fabio; Steinhoff, Martin; Amadesi, Silvia; Guerrini, Remo; Tognetto, Michele; Trevisani, Marcello; Créminon, Christophe; Bertrand, Claude; W. Bunnett, Nigel; M. Fabbri, Leonardo; Salvadori, Severo; Geppetti, Pierangelo

doi:10.1164/ajrccm.161.5.9907133

Public

Presence and Bronchomotor Activity of Protease-Activated Receptor-2 in Guinea Pig Airways

Published in American Journal of Respiratory and Critical Care Medicine • May 1, 2000

Authors:

Fabio Luigi Massimo Ricciardolo

Martin Steinhoff

Silvia Amadesi

Abstract

The protease activated receptor-2 (PAR-2) belongs to a family of G-protein-coupled receptors that are activated by proteolysis. Trypsin cleaves PAR-2, exposing an N-terminal tethered ligand (SLIGRL) that activates the receptor. Messenger RNA (mRNA) for PAR-2 was found in guinea pig airway tissue by ...

Subject

Medicine

Guinea pig

Protease

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