Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry.

PA, Egner; JD, Groopman; JS, Wang; TW, Kensler; MD, Friesen

doi:10.1021/tx060108d

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Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry.

Shared by NobleBlocks on Sep 1, 2006 • 12:00 AM UTC

Authors:

Egner PA

Groopman JD

Wang JS

Abstract

We report validation of the first isotope dilution mass spectrometry method for determination of aflatoxin B(1)-N(7)-guanine (AFB(1)-N(7)-Gua), a major human aflatoxin-DNA adduct that is excreted in the urine. Measurement of urinary AFB(1)-N(7)-Gua, a biomarker of the biologically effective dose fol...

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