Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct

Hoffmann, Patrick; Hofmeister, Robert; Brischwein, Klaus; Brandl, Christian; Crommer, Sandrine; Bargou, Ralf; Itin, Christian; Prang, Nadja; A. Baeuerle, Patrick

doi:10.1002/ijc.20908

Public

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct

Shared by NobleBlocks on Feb 1, 2005 • 12:00 AM UTC

Authors:

Patrick Hoffmann

Robert Hofmeister

Klaus Brischwein

Abstract

Abstract Certain bispecific antibodies exhibit an extraordinary potency and efficacy for target cell lysis by eliciting a polyclonal T‐cell response. One example is a CD19‐/CD3‐bispecific single‐chain antibody construct (bscCD19xCD3), which at femtomolar concentrations can redirect cytotoxic T cells...

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