Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct

Hoffmann, Patrick; Hofmeister, Robert; Brischwein, Klaus; Brandl, Christian; Crommer, Sandrine; C. Bargou, Ralf; Itin, Christian; Prang, Nadja; A. Baeuerle, Patrick

doi:10.1002/ijc.20908

Public

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct

Published in International Journal of Cancer • Feb 1, 2005

Authors:

Patrick Hoffmann

Robert Hofmeister

Klaus Brischwein

Abstract

Certain bispecific antibodies exhibit an extraordinary potency and efficacy for target cell lysis by eliciting a polyclonal T-cell response. One example is a CD19-/CD3-bispecific single-chain antibody construct (bscCD19xCD3), which at femtomolar concentrations can redirect cytotoxic T cells to elimi...

Subject

Cytotoxic T cell

Antibody

CD19

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