Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery.

Husam, Ghanim,; Scott V, Monte,; Chang Ling, Sia,; Sanaa, Abuaysheh,; Kelly, Green,; Joseph A, Caruana,; Paresh, Dandona,

doi:10.1210/jc.2011-3284

Public

Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery.

Published in The Journal of clinical endocrinology and metabolism • Jul 1, 2012

Authors:

Ghanim, Husam

Monte, Scott V

Sia, Chang Ling

Abstract

OBJECTIVE: Obesity and type 2 diabetes are associated with an increase in the incidence and prevalence of Alzheimer's disease (AD) and an impaired cognitive function. Because peripheral blood mononuclear cells (MNC) express amyloid precursor protein (APP), the precursor of β-amyloid, which forms the...

Subject

Adult

Alzheimer Disease

Amyloid beta-Protein Precursor

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