Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome

B. Gordon, Leslie; E. Kleinman, Monica; T. Miller, David; Neuberg, Donna; Giobbie‐Hurder, Anita; Gerhard‐Herman, Marie; Smoot, Leslie; M. Gordon, Catherine; Cleveland, Robert; D. Snyder, Brian; J. Fligor, Brian; Robert Bishop, W.; Statkevich, Paul; Regen, Amy; L. Sonis, Andrew; Riley, Susan; Ploski, Christine; Correia, Annette; Quinn, Nicolle; J. Ullrich, Nicole; Nazarian, Ara; G. Liang, Marilyn; Y. Huh, Susanna; Schwartzman, Armin; W. Kieran, Mark

doi:10.1073/pnas.1202529109

Public

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome

Published in Proceedings of the National Academy of Sciences • Sep 24, 2012

Authors:

Leslie B. Gordon

Monica E. Kleinman

David T. Miller

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging syndrome caused by a mutation in LMNA that produces the farnesylated aberrant lamin A protein, progerin. This multisystem disorder causes failure to thrive and accelerated atherosclerosis leading to ea...

Subject

Progeria

LMNA

Farnesyltransferase

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!