Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa

Edwards-Smith, Catherine; R. Jonsson, Julie; M. Purdie, David; S. Bansal, Amolak; Shorthouse, Claudia; E. Powell, Elizabeth

doi:10.1002/hep.510300207

Public

Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa

Published in Hepatology • Aug 1, 1999

Authors:

Catherine Edwards-Smith

Julie R. Jonsson

David M. Purdie

Abstract

Serum levels of interleukin-10 (IL-10) are elevated in a proportion of patients with untreated chronic hepatitis C, and this may compromise the host immune response to the virus. The capacity for IL-10 production varies according to the genetic composition of the IL-10 locus. We examined the inherit...

Subject

Interferon alfa

Medicine

Chronic hepatitis

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