Pan-cancer patterns of somatic copy number alteration

Zack, Travis; E. Schumacher, Steven; L. Carter, Scott; D. Cherniack, Andrew; Saksena, Gordon; Tabak, Barbara; S. Lawrence, Michael; Zhang, Cheng‐Zhong; A. Wala, Jeremiah; H. Mermel, Craig; Sougnez, Carrie; Gabriel, Stacey; Hernandez, Bryan; Shen, Hui; W. Laird, Peter; Getz, Gad; Meyerson, Matthew; Beroukhim, Rameen

doi:10.1038/ng.2760

Public

Pan-cancer patterns of somatic copy number alteration

Published in Nature Genetics • Sep 26, 2013

Authors:

Travis Zack

Steven E. Schumacher

Scott L. Carter

Abstract

Rameen Beroukhim and colleagues analyzed somatic structural alterations in 12 tumor types. Whole-genome doubling was found in over a third of all cancers, associated with TP53 mutation. Fifteen new significantly mutated candidate driver genes were found associated with recurrently amplified or delet...

Subject

Biology

Somatic cell

Cancer

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