Sifuvirtide Screens Rigid Membrane Surfaces. Establishment of a Correlation between Efficacy and Membrane Domain Selectivity among HIV Fusion Inhibitor Peptides

G. Franquelim, Henri; M. S. Loura, Luís; C. Santos, Nuno; A. R. B. Castanho, Miguel

doi:10.1021/ja711247n

Public

Sifuvirtide Screens Rigid Membrane Surfaces. Establishment of a Correlation between Efficacy and Membrane Domain Selectivity among HIV Fusion Inhibitor Peptides

Published in Journal of the American Chemical Society • Apr 15, 2008

Authors:

Henri G. Franquelim

Luís M. S. Loura

Nuno C. Santos

Abstract

Sifuvirtide, a 36 amino acid negatively charged peptide, is a novel and promising HIV fusion inhibitor, presently in clinical trials. Because of the aromatic amino acid residues of the peptide, its behavior in aqueous solution and the interaction with lipid-membrane model systems (large unilammelar ...

Subject

Chemistry

Selectivity

Membrane

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