Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

Furuse, Mikio; Itoh, Masahiko; Hirase, Tetsuaki; Nagafuchi, Akira; Yonemura, Shigenobu; Tsukita, Shöichiro; Tsukita, Shöichiro

doi:10.1083/jcb.127.6.1617

Public

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

Published in The Journal of Cell Biology • Dec 15, 1994

Authors:

Mikio Furuse

Masahiko Itoh

Tetsuaki Hirase

Abstract

Occludin is an integral membrane protein localizing at tight junctions (TJ) with four transmembrane domains and a long COOH-terminal cytoplasmic domain (domain E) consisting of 255 amino acids. Immunofluorescence and laser scan microscopy revealed that chick full-length occludin introduced into huma...

Subject

Occludin

Biology

Tight junction

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