Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model

Wakabayashi, Kiryo; Nagai, Atsushi; Md. Sheikh, Abdullah; Shiota, Yuri; Narantuya, Dashdemberel; Watanabe, Tatsuzo; Masuda, Junichi; Kobayashi, Shotai; Up Kim, Seung; Yamaguchi, Shuhei

doi:10.1002/jnr.22279

Public

Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model

Published in Journal of Neuroscience Research • Nov 2, 2009

Authors:

Kiryo Wakabayashi

Atsushi Nagai

Abdullah Md. Sheikh

Abstract

Previous studies have suggested that intravenous transplantation of mesenchymal stem cells (MSCs) in rat ischemia models reduces ischemia-induced brain damage. Here, we analyzed the expression of neurotrophic factors in transplanted human MSCs and host brain tissue in rat middle cerebral artery occl...

Subject

Neurotrophic factors

Transplantation

Basic fibroblast growth factor

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