CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction

Lee, Alvin; Roylance, Rebecca; Sander, Jil; Gorman, Patricia; Endesfelder, David; Kschischo, Maik; P. Jones, Neil; East, Philip; Nicke, Barbara; D. Spassieva, Stefka; M. Obeid, Lina; J. Birkbak, Nicolai; Szállási, Zoltán; C. McKnight, Nicole; J. Rowan, Andrew; Speirs, Valerie; M. Hanby, Andrew; Downward, Julian; A. Tooze, Sharon; Swanton, Charles

doi:10.1002/path.2998

Public

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction

Published in The Journal of Pathology • Sep 27, 2011

Authors:

Alvin Lee

Rebecca Roylance

Jil Sander

Abstract

Chromosomal instability (CIN) has been implicated in multidrug resistance and the silencing of the ceramide transporter, CERT, promotes sensitization to diverse cytotoxics. An improved understanding of mechanisms governing multidrug sensitization might provide insight into pathways contributing to t...

Subject

Autophagy

Polyploid

Programmed cell death

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!