Silencing of Long Noncoding RNA MALAT1 by miR-101 and miR-217 Inhibits Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells

Wang, Xinyu; Li, Meng; Wang, Zhiqiong; Han, Sichong; Tang, Xiaohu; Ge, Yunxia; Zhou, Liqing; Zhou, Changchun; Yuan, Qipeng; Yang, Ming

doi:10.1074/jbc.m114.596866

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Silencing of Long Noncoding RNA MALAT1 by miR-101 and miR-217 Inhibits Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells

Published in Journal of Biological Chemistry • Dec 24, 2014

Authors:

Xinyu Wang

Meng Li

Zhiqiong Wang

Abstract

MALAT1, a highly conserved long noncoding RNA, is deregulated in several types of cancers. However, its role in esophageal squamous cell carcinoma (ESCC) and its posttranscriptional regulation remain poorly understood. In this study we provide first evidences that a posttranscriptional regulation me...

Subject

MALAT1

Gene silencing

microRNA

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