Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

W. Pierce, Jacqueline; Schoenleber, Robert; Jesmok, Gary; L. Best, Jennifer; A. Moore, Sarah; Collins, Tucker; E. Gerritsen, Mary

doi:10.1074/jbc.272.34.21096

Public

Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

Published in Journal of Biological Chemistry • Aug 1, 1997

Authors:

Jacqueline W. Pierce

Robert Schoenleber

Gary Jesmok

Abstract

We have identified two compounds that inhibit the expression of endothelial-leukocyte adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin. These compounds act by inhibiting tumor necrosis factor-alpha-induced phosphorylation of IkappaB-alpha, resul...

Subject

Phosphorylation

Cell adhesion molecule

Tumor necrosis factor alpha

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