Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy

C. Rockey, Don; M. Vierling, John; Mantry, Parvez; Ghabril, Marwan; S. Brown, Robert; Alexeeva, Olga; А. Зупанец, И.; Б. Гриневич, В.; Baranovsky, Andrey; Dudar, Larysa; D. Fadieienko, G.; K. Kharchenko, N.; Klaryts'ka, Iryna; Morozov, Vyacheslav; Grewal, Priya; M. McCashland, Timothy; K. Reddy, Gautham; Rajender Reddy, K.; Syplyviy, Vasyl; M. Bass, Nathan; Dickinson, Klara; J. Norris, Catherine; F. Coakley, Dion; Mokhtarani, Masoud; F. Scharschmidt, Bruce

doi:10.1002/hep.26611

Public

Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy

Published in Hepatology • Jul 11, 2013

Authors:

Don C. Rockey

John M. Vierling

Parvez Mantry

Abstract

UNLABELLED: Glycerol phenylbutyrate (GPB) lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion in the form of phenylacetyl glutamine, which is excreted in urine. This randomized, double-blind, placebo-controlled phase II trial enrolled 178 patients with cirrhosis, in...

Subject

Phenylbutyrate

Medicine

Double blind

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