Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.

Subramaniam, Aruljothi; K Shanmugam, Muthu; Perumal, Ekambaram; Li, Feng; Nachiyappan, Alamelu; Dai, Xiaoyun; Nanjunda Swamy, Shivananju; Seok Ahn, Kwang; Prem Kumar, Alan; K H Tan, Benny; Man Hui, Kam; Sethi, Gautam

doi:10.1016/j.bbcan.2012.10.002

Public

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.

Shared by NobleBlocks on Jan 1, 2013 • 12:00 AM UTC

Authors:

Aruljothi Subramaniam

Muthu K Shanmugam

Ekambaram Perumal

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, and is also the fourth most common cancer worldwide with around 700,000 new cases each year. Currently, first line chemotherapeutic drugs used for HCC include fluorouracil, cisplatin, doxorubicin, paclitaxel and mitomycin, but mo...

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