Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Published in The Journal of Neuroscience • Aug 13, 2008
Authors:,,
Suzanne E. Hickman
Elizabeth K. Allison
Joseph El Khoury
Abstract
Early microglial accumulation in Alzheimer's disease (AD) delays disease progression by promoting clearance of β-amyloid (Aβ) before formation of senile plaques. However, persistent Aβ accumulation despite increasing microglial numbers suggests that the ability of microglia to clear Aβ may decrease ...
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