The Analgesic Efficacy and Safety of a Novel Intranasal Morphine Formulation (Morphine plus Chitosan), Immediate Release Oral Morphine, Intravenous Morphine, and Placebo in a Postsurgical Dental Pain Model

S. Christensen, Kyle; E. Cohen, Amy; Mermelstein, Fred; A. Hamilton, Douglas; D McNicol, Ewan; Babul, Najib; B. Carr, Daniel

doi:10.1213/ane.0b013e318187b952

Public

The Analgesic Efficacy and Safety of a Novel Intranasal Morphine Formulation (Morphine plus Chitosan), Immediate Release Oral Morphine, Intravenous Morphine, and Placebo in a Postsurgical Dental Pain Model

Published in Anesthesia & Analgesia • Nov 13, 2008

Authors:

Kyle S. Christensen

Amy E. Cohen

Fred Mermelstein

Abstract

BACKGROUND: Opioids are standard treatment for postoperative pain. In this study, we compared the safety and efficacy of intranasal (i.n.) morphine to i.v. and oral morphine and placebo. METHODS: Two-hundred-twenty-five patients with moderate-to-severe pain after third molar extraction were randomiz...

Subject

Medicine

Morphine

Anesthesia

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