Hypoxia‐induced increase in the production of extracellular matrix proteins in systemic sclerosis

H. W. Distler, Jörg; Jüngel, Astrid; Pileckytė, Margarita; Zwerina, Jochen; A. Michel, Beat; E. Gay, Renate; Kowal‐Bielecka, Otylia; Matucci‐Cerinic, Marco; Schett, Georg; H. Marti, Hugo; Gay, Steffen; Distler, Oliver

doi:10.1002/art.23074

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Hypoxia‐induced increase in the production of extracellular matrix proteins in systemic sclerosis

Published in Arthritis & Rheumatism • Nov 29, 2007

Authors:

Jörg H. W. Distler

Astrid Jüngel

Margarita Pileckytė

Abstract

OBJECTIVE: Insufficient angiogenesis with tissue ischemia and accumulation of extracellular matrix are hallmarks of systemic sclerosis (SSc). Based on the severely decreased oxygen levels in the skin of patients with SSc, we aimed to investigate the role of hypoxia in the pathogenesis of SSc. METHOD...

Subject

Extracellular matrix

Fibronectin

Hypoxia (environmental)

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