Signaling via ErbB2 and ErbB3 Associates with Resistance and <i>Epidermal Growth Factor Receptor</i> (<i>EGFR</i>) Amplification with Sensitivity to EGFR Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cells

Erjala, Kaisa; Sundvall, Maria; T. Junttila, Teemu; Zhang, Na; Savisalo, Mika; Mali, Pekka; Kulmala, Jarmo; Pulkkinen, Jaakko; Grenman, Reidar; Elenius, Klaus

doi:10.1158/1078-0432.ccr-05-2404

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Signaling via ErbB2 and ErbB3 Associates with Resistance and Epidermal Growth Factor Receptor (EGFR) Amplification with Sensitivity to EGFR Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cells

Shared by NobleBlocks on Jul 1, 2006 • 12:00 AM UTC

Authors:

Kaisa Erjala

Maria Sundvall

Teemu T. Junttila

Abstract

Abstract Purpose: The epidermal growth factor receptor (EGFR) inhibitor gefitinib (Iressa) has shown antitumor activity in clinical trials against cancers, such as non–small cell lung cancer and head and neck squamous cell carcinoma (HNSCC). Research on non–small cell lung cancer has elucidated fact...

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