Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

B. Treasure, Charles; Larry Klein, J.; S. Weintraub, William; David Talley, J.; Stillabower, Michael; S. Kosinski, Andrzej; Zhang, Jian; J. Boccuzzi, Stephen; C. Cedarholm, John; Wayne Alexander, R.

doi:10.1056/nejm199502233320801

Public

Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

Published in New England Journal of Medicine • Feb 23, 1995

Authors:

Charles B. Treasure

J. Larry Klein

William S. Weintraub

Abstract

BACKGROUND: Impaired endothelium-mediated relaxation contributes to vasospasm and myocardial ischemia in patients with coronary artery disease. We hypothesized that cholesterol-lowering therapy with the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin could improve endothelium-me...

Subject

Medicine

Lovastatin

Placebo

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