Efficient downregulation of VEGF in retinal pigment epithelial cells by integrin ligand-labeled liposome-mediated siRNA delivery

Lu, Da‐Wen; Shiau, Chia-Yang; Chiang, Chiao‐Hsi; , Chen; Yeh, Ming‐Kung

doi:10.2147/ijn.s39622

Public

Efficient downregulation of VEGF in retinal pigment epithelial cells by integrin ligand-labeled liposome-mediated siRNA delivery

Published in International Journal of Nanomedicine • Jul 1, 2013

Authors:

Da‐Wen Lu

Chia-Yang Shiau

Chiao‐Hsi Chiang

Abstract

BACKGROUND: The purpose of this study was to demonstrate the effectiveness of an integrin peptide ligand-labeled liposomal delivery system loaded with vascular endothelial growth factor (VEGF)-siRNA in a model study of gene therapy for retinopathy using human retinal pigment epithelial cells. METHOD...

Subject

Liposome

Cytotoxicity

Transfection

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