The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia

Herishanu, Yair; Pérez‐Galán, Patricia; Liu, Delong; Biancotto, Angélique; Pittaluga, Stefania; Vire, Bérengère; Gibellini, Federica; Njuguna, Ndegwa; Lee, Elinor; Stennett, Lawrence; Raghavachari, Nalini; Liu, Poching; Philip McCoy, J.; Raffeld, Mark; Stetler‐Stevenson, Maryalice; M. Yuan, Constance; M. Sherry, Richard; C. Arthur, Diane; Marić, Irina; White, Therese; E. Marti, Gerald; J. Munson, Peter; H. Wilson, Wyndham; Wiestner, Adrian

doi:10.1182/blood-2010-05-284984

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The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia

Published in Blood • Oct 13, 2010

Authors:

Yair Herishanu

Patricia Pérez‐Galán

Delong Liu

Abstract

Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes, involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes (LN). A role of the tissue microenvironment in the pathogenesis of CLL is hypothesized based on in vitro observations, but its contr...

Subject

Chronic lymphocytic leukemia

Cancer research

breakpoint cluster region

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