Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Miura, Kouichi; Yang, Ling; van Rooijen, Nico; Ohnishi, Hirohide; Seki, Ekihiro

doi:10.1152/ajpgi.00365.2011

Public

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Published in American Journal of Physiology-Gastrointestinal and Liver Physiology • Mar 23, 2012

Authors:

Kouichi Miura

Ling Yang

Nico van Rooijen

Abstract

Inflammatory cell infiltration in the liver is a hallmark of nonalcoholic steatohepatitis (NASH). The chemokine-chemokine receptor interaction induces inflammatory cell recruitment. CC-chemokine receptor (CCR)2 is expressed on hepatic macrophages and hepatic stellate cells. This study aims to invest...

Subject

CCR2

Chemokine

Steatohepatitis

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